Currently viewing the category: "pneumonia"

A rare fungus is being blamed for fifteen deaths in the Pacific Northwest from British Columbia to California over the last six years.  Don’t worry grungers…not your magic mushrooms, but a fungus called Cryptococcus gattii, which grows on or around trees.  Breathing its microscopic spores can cause persistent cough, headache and shortness of breath, and even pneumonia or meningitis in some people.

Before you get too freaked about it, the risk is still very low.  First, it’s still a relatively rare species in North America–C. gattii is found primarily in the tropics.  Second, the people who have died from infection of the fungus in the U.S. and Canada all had predisposing illnesses.  Third, many more have likely contracted illness related to the fungus but it has been mild.  So you don’t have to avoid nature or the outdoors just yet.

The fungal illness showed up initially in British Columbia, Canada in 1999.  It has since migrated southward, and in 2004, there have been 43 cases in Oregon, 15 in Washington, one in California and one in Idaho, the CDC reported this week.  Canadian officials report 272 illnesses since cases were first detected.  The death rate there from the fungal infection have been reported at 9%.

Humans are not the only ones becoming infected, either.  To date more than 50 cases of cats, dogs, ferrets, elk and porpoises have been reported in the U.S.

Living in Southern California, I can’t help but think of Coccidioides immitis, the causative agent in Valley fever.  Hoping my brothers and sisters up in Vancouver, Seattle and Portland don’t have to deal with that type of scenario.  I, along with doctors in the region and public health officials, will be keeping eyes and ears open.  I’ll keep you informed.

Wanna know the best way to test a new experimental vaccine? Give it to unsuspecting poor people. Want to know how to get away with shoddy recruitment practices when you get caught–make sure those poor people are in Latin America. Don’t believe me? Read on.

According tho the Argentina’s food and drug administration, an investigation is being launched into the possible link between an “experimental” vaccine and the deaths of 14 children in Argentina and Panama. Pharmaceutical maker, GlaxoSmithKline, developed Synflorix as a vaccine to combat pneumonia–a noble undertaking–but sources say that the mega-drug maker may have used dubious tactics to recruit volunteers. One watchdog group says that many participants were not told of the experimental nature of the vaccine. “They didn’t explain to the parents that this was an experimental vaccine, and a lot of the parents who signed consent forms were illiterate,” said Ana Maria Marchesse, a pediatrician who heads the Health Professionals’ Labor Association in the northern Argentine province of Santiago del Estero, where seven of the 14 children died.

GlaxoSmithKline defends itself by saying that safety is always their utmost concern. In fact, they say, the number of pneumonia deaths among the experimental group was four times less than in the general population. Not bad numbers.

But “Uh, uh, uh, no, no, no…,” say doctors in the Santiago del Estero region of Argentina. They report that they witnessed “poor ethical management” of patient recruitment. “In some cases, they first gave them the vaccine and then gave them a 13-page consent form to sign that I had to read three times to understand,” Dr. Marchesse added.

A case of he said, she said? Hmmm…what do you think? I think we’ll be hearing more of this in the near future.

As medical technology advances, modern society is increasingly faced with tough ethical questions–questions regarding right to life and quality of life issues. Take for example a new study which suggests that antibiotics are overused in people dying of dementia diseases and should be considered more carefully in light of the growing problem of drug-resistant superbugs. In other words, should people at the end stage of disease be given life-saving treatments despite the fact that time is not on their side? Or should medical practitioners consider the larger implications to the public health as a whole?

According to study co-author Dr. Susan Mitchell, a senior scientist with the Harvard-affiliated Hebrew Senior Life Institute for Aging Research in Boston, “Advanced dementia is a terminal illness; if we substituted ‘end-stage cancer’ for ‘advanced dementia,’ I don’t think people would have any problem understanding this.” What she is referring to is withholding antibiotics from people in the end-stages of Alzheimer’s disease, a fatal brain disease. Although many dementia patients die from infections like pneumonia, the underlying cause of illness and deterioration is damage to brain cells.

In the study, over two hundred people with advanced stage dementia residing in nursing homes in the Boston area were followed over an eighteen month period or until they died. Almost half the subjects died during the study. All subjects failed to recognize loved ones, had stopped speaking, were unable to walk or feed themselves, and were incontinent. Researchers looked at the patient’s medical records and found that 42% received antibiotics–many intravenously–within two weeks of their death. And here’s the kicker: The closer the patients were to dying, the more likely they were to receive antibiotics.

The problem with the practice of administering antibiotics to people near death is that we are in the midst of a superbug (antibiotic resistant strains of bacteria) epidemic; and the indiscriminate use of anti-bacterial medicines is more than a little to blame. Liberal prescribing of antibiotics is common in nursing homes, in children with ear infections, in adults with coughs and sore throats, and in many other ailments which, for the most part, will resolve on their own over time, or for which antibiotics are useless, like viral infections. But the fact is that, in nursing homes, the standard of care is for doctors to see the residents only one time per month or once every two months. According to Dr. Daniel Brauner, a geriatrician and ethicist at the University of Chicago Medical Center who was not involved in the study, “I’m sure a lot of these antibiotics were prescribed over the telephone.” I’m sure of that, too.

So the question remains: Should medical treatments be administered to people who are at the end stage of terminal illness? I’m certain there is no real answer. If the person is your loved one–your wife, husband, mother, father, and so forth–I’m quite convinced the answer will be YES! We all want the extra time with our closest family members. But in the bigger picture, perhaps a dignified death with the help “the old man’s friend”, as pneumonia was once called, is in order. As bioethicist Bruce Jennings, consultant at the Hastings Center, a research institute on medical ethics, says, “You might rescue the patient from life-threatening pneumonia and they live a few days, weeks or even months longer, but the extra time you have bought them by that rescue is not beneficial.”

Academy-award nominated actor Heath Ledger was found dead in his Manhattan apartment this afternoon, the apparent victim of a drug overdose. Although the exact cause of death is as of yet unknown, prescription sleeping pills were found strewn around his bed, recent reports disclose. Ledger apparently had some trouble sleeping recently and told the New York Times in November that he was taking Ambien. He also was reported to be suffering from pneumonia.

This a very sad and tragic story and my heart goes out to Heath Ledger’s family. Although there is no way, yet, to know what happened exactly, I wouldn’t be surprised if the combination of pneumonia (hacking, phlegmy congestion) and sleeping pills did him in. Ambien, in particular, can close off the airway and cause breathing difficulties. Add to that a sedative effect, and it may be a recipe for disaster. Ambien can also cause anaphylaxis–an acute and severe allergic reaction that can lead to death within minutes.

Let me say it loud and clear: Ambien is bad stuff! Don’t take it. I’ve reported the dangers of this drug extensively on the Dr. Nick Show (Episode 3–Lifestyle Drugs). It has side effects (read them here–this stuff is no joke). According to the Mayo clinic, you don’t want to take Ambien if you are suffering from respiratory conditions. Duh! YOU HAVE GOT TO READ THE LABELS! Period. Just because a drug is doctor prescribed doesn’t mean diddly. It’s everyone’s responsibility to know exactly what they are taking and what the dangers are at all times.

Google Ambien and pick an information site. Pick one–any one. The side effects are there. Don’t think it can’t happen to you. Heath Ledger was only 28 years old. He was young and vibrant and healthy. It could happen to anyone. Please, read the instructions, and if you’re not sure–don’t take it!

Rest in Peace Good Soul.

Heath Ledger 1979-2008.

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