Currently viewing the category: "psychopathy"

Ever wonder what motivates people to kill, rape, or torture? Ever wonder what differences exist between people who do this and you? Well scientists have found a piece to the puzzle: Psychopathic people have disruptions in their neural connections in parts of the brain that deal with emotions, and handle impulses and decision making.

Recent research published in the latest issue of Molecular Psychiatry shows that the connection between the amygdala, which processes emotions, and the orbitofrontal cortex, which handles impulses and decisions, are dysfunctional. These two brain regions function together to produce actions based on conscious decision. We use emotions to guide these decisions.

Psychopathy is a mental disorder characterized by amoral and antisocial behavior, lack of ability to love or establish meaningful personal relationships, extreme egocentricity, and failure to learn from experience. Psychopaths–people exhibiting psychopathy–have a disruption–researchers called them “potholes” in the neuronal connections (between nerve cells) that allow this function to proceed unimpeded. Normal, non-psychopathic people have no disruptions or potholes.

Although it was only a matter of time before the physiological and structural deformities in psychopathy were uncovered (this is true for all mental disorders, of which depression is not one to my estimation), the pothole findings are not what interest me. For my understanding, a physiological response is a given in any “disorder”. But I always ask the question, “Does the physiological change cause the disorder or is it the other way around?” When it comes to disorders of the mind, I think in general, the physiologic change is a result or manifestation of a faulty or dysfunctional mental process.

Think about this: our bodies are constantly changing, reshaping and reforming all the time, and our brains are no exception. Our nervous systems change and adapt to stimuli and the environment around us. We develop new neural connections and pathways as a response to stress. Stress can be environmental, mental, or simply learning new things. When we are imbalanced in our perceptions, polarized–that is, when we see more of one side than another–we create different pathways (and probably lose some) than when we are seeing both sides of a situation, when we are in balance. Mental polarity causes electrical charges, just like a battery. This electrical polarization in my opinion is what causes the potholes seen in psychopathy–which is an extreme form of charge. Revisit the definition of the disorder above–doesn’t it describe exactly what I am talking about here?

The unfortunate part of this type of finding is that the current paradigm in psychiatry (still the reigning authority on clinical mental health) is the biological model. The belief is that physiology is cause. In other words, it’s the physical dysfunction that leads to disorder. As a result, the typical treatment options are 1) find a drug to combat pothole formation or 2) screen potential pothole developers and catch before psychopathic behavior manifests–both futile in my opinion.

What I believe needs to be done–and we are probably years off–is to work psychologically with these patients, try to regain perceptual balance through mental techniques, and then focus these techniques on all mental and psychological patients, regardless of the issue. But like I said, we are probably way off from that being the treatment method of choice. So until then we will simply have to marvel in discovery; and with regard to these latest findings, I am in awe.

Severe stress during pregnancy may help cause schizophrenia. So says a study out New York University School of Medicine. According to researchers, severe stress–like wars, natural disasters, terrorism, or sudden bereavement–can lead to epigenetic changes, which are changes in gene expression, not changes to the DNA itself.

The study looked at data from 88,829 people born in Jerusalem from 1964 to 1976. They wanted to see if an increase in schizophrenia occurred in babies born to women during the height of the 1967 Arab-Israeli Six-Day War. What they found is astounding: babies born to mothers who were two months pregnant in June of 1967 were significantly more likely to develop schizophrenia. The height of bombing in Jerusalem was a three day period from June 5-7.

Females born during this period (January 1968 to be exact) were 4.2 times more likely to develop schizophrenia than the 1.1 % of the population which is the global norm. Males born during this period were 1.2 times more likely to develop the mental illness. Wow! Although the researchers didn’t rule out a genetic link–that is, the babies had a high family risk for developing schizophrenia–it is unlikely. While schizophrenia in the general population has some family ties, the majority of cases do not. So epigenetics seems to be the logical mechanism.

I find these results fascinating, because I’m a firm believer that we all have every gene, but it’s whether or not it’s expressed that counts. This would explain some seemingly random human variations, like gender identity disorders, psychopathy, and schizophrenia. And it makes complete sense that a strong connection exists between Mom’s experiences during gestation and how baby forms.

In epigenetics, as it is understood and discussed today, we are talking about a narrow form of gene expression, a once in a lifetime event. In other words, humans are not susceptible to environmentally induced genetic changes multiple times in their lifetime; major genetic variations occur during gestational development only. In the case of severe stress, the stress hormones can affect the placenta, ultimately changing the environment of the fetus, which then changes in response.

But wait! Don’t freak out, soon to be mom’s: we’re talking about severe stress here, not simply getting in a fight with baby’s daddy. I reported in an earlier post that this just isn’t the case, so unless you’re involved in a major trauma, you probably have nothing to worry about. But I think we will learn in the near future just how much severe stressors during pregnancy can affect the unborn child. Any thoughts?

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