Currently viewing the category: "selective serotonin reuptake inhibitors (SSRIs)"

Easy Ain’t Always What it Seems

By On · Add Comment · In 60 Minutes, antidepressants, depression, Food and Drug Administration (FDA), placebo, prescription drugs, selective publication, selective serotonin reuptake inhibitors (SSRIs)

60 Minutes did a great piece over the weekend on the business of depression–that’s right, BIG business–and whether the product that’s being sold to America (and the rest of the western world) is actually doing what it’s supposed to. Some experts (myself included) believe that the popular (read: highly prescribed) depression drugs–the selective serotonin reuptake inhibitors (SSRIs)–don’t do a whole lot for people that are moderately depressed, and the data seems to back up that notion.

However, antidepressants continue to be some of the most prescribed drugs in the U.S., and most of those people fall in the center of a bell-shaped curve. In other words, most people taking antidepressants probably aren’t getting much from them, as Harvard psychologist and researcher, Irving Kirsch articulates in the video. According to his research, many of the studies that show antidepressants not doing much more than placebo have been hidden by the manufacturers who lead the studies.

We call this selective publication, and I’ve been reporting on this phenomenon within the antidepressant manufacturing industry for over four years. In 2008, research showed that only one third of the studies conducted on SSRI antidepressants ever made its way out to the public. Can you guess which third gets published?

In the 60 Minutes piece below, you’ll see Dr. Thomas Laughren, FDA Director of the Division of Psychiatry Products rationalize why it only takes two favorable studies–even if ten come back unfavorable–for a drug to get approval by the FDA. Oddly, he doesn’t mention “cha-ching $$$” anywhere in the piece. Hmmm…

Listen, I’m all for big business–a capitalist to the core–but there’s something wrong with pushing a drug onto millions of people, including children as young as six years old, when it isn’t doing exactly what it’s supposed to. And I wouldn’t care except there is also evidence that some of the side effects aren’t benign, or whether they are permanent. And that’s playing with people’s lives.

Again, I do not pull the public out of the equation because too many people are looking for an easy way out–and antidepressants sure promise that. Watch the piece below to see why easy ain’t always what it seems to be.

Something Exciting About Anti-Depressants

By On · Add Comment · In antidepressants, Lexapro, Rehabilitation Institute of Chicago, selective serotonin reuptake inhibitors (SSRIs), serotonin, spinal cord injuries

Finally, something to get excited about selective serotonin reuptake inhibitors (SSRIs)–they might just have a future in spinal cord injury rehabilitation. That’s right, your regular ol’ run-of-the-mill antidepressants have been shown to get people with spinal cord injuries walking faster. Now that’s exciting!

A study conducted at the Rehabilitation Institute of Chicago built on previous studies showing that giving animals serotonin-like drugs after spinal cord injuries promoted recovery of walking when paired with an intensive training program. It looked at 50 patients with partial spinal cord injuries, 34 of which could walk, albeit slowly, previous to the study. All 50 went through an eight-week rehabilitative walking program on a treadmill, assisted by a robot or physical therapist. Up to 40 percent of their body weight was supported in a harness.

Five hours before training, some were given 10 mg of Lexapro, and some a placebo. Although both groups showed overall improvement, the Lexapro group did so faster. Selective serotonin reuptake inhibitors–like Prozac, Lexapro, Luvox and Zoloft–work by preventing the reuptake of the neurotransmitter serotonin by the nerve cells of the brain. In so doing, they allow the concentration of serotonin to remain elevated in the neural synapses, regulating mood (debatable but the reigning theory, anyway).

In this case, the drugs appear to work by increasing muscle spasms that people with spinal cord injuries typically experience, says George Hornby, a research scientist involved in the study. Most doctors consider these spasms negative, but Hornsby and colleagues believe that they mimic reflexes, which spinal cord injury patients “rely on [to walk].”

The volunteers only received the antidepressants on the day of training, yet the benefits continued long after the drug was out of their systems. Hornby thinks the drug is strengthening the residual connections between the brain and the spinal cord. “It helps you drive that muscle harder, and it’s easier for the brain to activate the muscle,” he said.

I find this research exiting because, along with the obvious, I pretty much think antidepressants are more hype than help. Oh, they change brain chemistry, no doubt; and these changes lead to mood alteration, but is this type of mood alteration ultimately what’s best for the person taking them? Not as far as I can see.

But I also acknowledge that all coins have a flip side; and in the gold-standard antidepressant therapy, we now have a tails to the “we cure depression” heads of the biochemical theory of mental “illness”. With these latest findings, I hail the possibilities of helping people with spinal cord injuries walk again–sooner, and maybe even better than the current recovery rate and results. So hang on tight people because you may never hear this out my brain again, but bravo! to the selective serotonin reuptake inhibitors.

More Risks Tied to Antidepressants

By On · Add Comment · In antidepressants, gastrointestinal bleeding, magic bullet, selective serotonin reuptake inhibitors (SSRIs)
Seems like the risks keep piling up for antidepressants. Selective serotonin reuptake inhibitors (SSRIs) like Prozac and Paxil have enough side effects to fill a book, like:

  • Dry mouth
  • Urinary retention
  • Blurred vision
  • Constipation
  • Sedation (can interfere with driving or operating machinery)
  • Sleep disruption
  • Weight gain
  • Headache
  • Nausea
  • Gastrointestinal disturbance/diarrhea
  • Abdominal pain
  • Inability to achieve an erection (limp D)
  • Inability to achieve an orgasm (men and women)
  • Loss of libido
  • Agitation
  • Anxiety

They have also been proven to increase suicidality (have you read my book?). And if taken with monoamine oxidase inhibitors (MAOIs), another type of antidepressant, the combination can kill you. But if that ain’t enough, a new study has come out linking the SSRI antidepressants to intestinal bleeding. Woowee! Ever poop blood, boy? Keep taking that Prozac and you just might.

Never fear, though, medical science has an answer. According to the research team, the gastrointestinal bleeding associated with antidepressant use can be easily remedy with…a simple antacid. No really, a magic bullet is all that’s needed. So if you’re hooked on antidepressants you should rest assured that by simply countering with an acid-suppressing medication, your risk for GI bleeding will be almost nil. You’ll simply need to deal with the other annoying side effects of the SSRIs and possibly a few more caused by the antacid. Piece of cake! Ain’t science grand?

And who may we thank for this study? Why AstraZeneca, that’s who…you know, the makers of Nexium and Prilosec, those quite useful acid-suppressing drugs that you’ll need to combat GI bleeding, and blah, blah, blah, blah, blah……..

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